Genetic susceptibility to Alzheimer disease

Trends Genet. 1995 Dec;11(12):504-8. doi: 10.1016/s0168-9525(00)89161-1.


Alzheimer disease (AD) is the leading cause of dementia in the elderly. Less than a decade ago, it was questioned as to whether or not genes were even involved in anything but rare early onset AD. Since that time, using a variety of genetic epidemiological and molecular biological techniques, four loci have been identified that play a role in the genetic susceptibility of AD. AD presents as a prototype of the power of genetic techniques in defining the etiology of a complex disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aged
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / genetics
  • Apolipoprotein E4
  • Apolipoproteins E / genetics
  • Chromosomes, Human, Pair 21
  • Down Syndrome / genetics
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Humans


  • Amyloid beta-Peptides
  • Apolipoprotein E4
  • Apolipoproteins E