Abstract
Sulphasalazine is cleaved into 5-aminosalicylic acid and sulphapyridine by colonic bacteria. The bulk of evidence favours sulphapyridine rather than 5-aminosalicylic acid as the active moiety (as well as the main producer of side-effects) though a therapeutic action from the 30% of sulphasalazine that is absorbed unaltered also cannot be excluded.
MeSH terms
-
Aminosalicylic Acids / pharmacology*
-
Anti-Inflammatory Agents / pharmacology*
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Antirheumatic Agents / pharmacology*
-
Humans
-
Mesalamine
-
Sulfapyridine / pharmacology*
-
Sulfasalazine / pharmacology*
Substances
-
Aminosalicylic Acids
-
Anti-Inflammatory Agents
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antirheumatic Agents
-
Sulfasalazine
-
Mesalamine
-
Sulfapyridine