Synergists for retinoid in cellular differentiation of human promyelocytic leukemia cells HL-60

Chem Pharm Bull (Tokyo). 1995 Oct;43(10):1827-9. doi: 10.1248/cpb.43.1827.


4-[5H-2,3-(2,5-Dimethyl-2,5-hexano)-5-methyldibenzo[b, e]diazepin-11-yl]benzoic acid (4) enhanced the differentiation-inducing activity of retinoic acid (1) and of a synthetic retinoid Am80 (2) toward human promyelocytic leukemia cells HL-60, although 4 alone did not induce differentiation. The synergistic effect of 4 on the activities of retinoids was also seen in suppression of proliferation of HL-60 cells.

MeSH terms

  • Cell Differentiation / drug effects*
  • Drug Synergism
  • Humans
  • Leukemia, Promyelocytic, Acute / pathology*
  • Receptors, Retinoic Acid / metabolism
  • Tretinoin / metabolism
  • Tretinoin / pharmacology*
  • Tumor Cells, Cultured


  • Receptors, Retinoic Acid
  • Tretinoin