A randomized, prospective study was undertaken to determine the efficacy of pressure garment therapy in patients with burns. Patients were randomly assigned to receive either pressure garment therapy or no pressure garment therapy. Patients were observed by use of the Vancouver Burn Scar Assessment Scale to assess the maturity of all involved areas. One hundred and twenty-two consecutive patients were enrolled in the study; 64 were assigned to pressure garment therapy and 58 to no pressure garment therapy. Eight of the patients receiving pressure garment therapy and nine receiving no pressure garment therapy were not involved in the follow-up. No significant differences were found between the two groups when age, body surface area burn, length of hospital stay, or time to wound maturation were compared.