Langerhans' cell histiocytosis: possible association with malignant germ cell tumour

J Clin Pathol. 1995 Oct;48(10):963-5. doi: 10.1136/jcp.48.10.963.


A rare case of adult onset Langerhans' cell histiocytosis associated with dysgerminoma in a 35 year old Chinese woman is reported. The patient had a history of dysgerminoma of left ovary 15 years previously and had undergone surgery followed by radiotherapy and an uneventful recovery. She presented again in March 1994, this time with a left clavicular mass, which was shown histologically to be Langerhans' cell histiocytosis. The report illustrates the probable association between the two lesions, with some discussion on the underlying pathogenesis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dysgerminoma / complications*
  • Dysgerminoma / pathology
  • Female
  • Histiocytosis, Langerhans-Cell / complications*
  • Histiocytosis, Langerhans-Cell / pathology
  • Humans
  • Ovarian Neoplasms / complications*
  • Ovarian Neoplasms / pathology