Factors associated with cytomegalovirus infection among human immunodeficiency virus type 1-seronegative and -seropositive women from an urban minority community

J Infect Dis. 1996 Jan;173(1):77-82. doi: 10.1093/infdis/173.1.77.

Abstract

Cytomegalovirus (CMV) seroprevalence and genital tract shedding in human immunodeficiency virus (HIV)-seronegative and HIV-seropositive women from an urban minority community were investigated. CMV seropositivity was high in both groups: 181 (95.2%) of 190 HIV-negative and 158 (90.3%) of 175 HIV-positive subjects. Cervicovaginal shedding was detected in 8 (4.4%) CMV-positive HIV-negative subjects and 31 (19.6%) HIV-positive subjects (odds ratio [OR], 5.28; P < .001). Multiple logistic regression analysis revealed that CMV shedding was independently associated with younger age (OR = 0.90; P < .001) and concurrent Chlamydia trachomatis or Neisseria gonorrhoeae infection (OR = 3.60; P = .08). However, shedding was observed over a broad age range in HIV-positive subjects, with 54.8% of shedders being > or = 30 years old. Among HIV-positive subjects, CMV shedding was also associated with decreased CD4 cell counts (P = .04) and, compared with HIV-negative subjects, was significantly higher (P < .001) among subjects with CD4 cell counts < 500 x 10(6)/L (26.5% in subjects with counts < or = 200 and 22.1% in subjects with counts of 201-499 x 10(6)/L).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS-Related Opportunistic Infections / complications
  • AIDS-Related Opportunistic Infections / epidemiology*
  • Adult
  • CD4 Lymphocyte Count
  • Chlamydia Infections / complications
  • Chlamydia trachomatis / isolation & purification
  • Cross-Sectional Studies
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections / complications
  • Cytomegalovirus Infections / epidemiology*
  • Female
  • Gonorrhea / complications
  • HIV Seronegativity*
  • HIV Seropositivity / complications*
  • HIV-1*
  • Humans
  • Minority Groups*
  • Neisseria gonorrhoeae / isolation & purification
  • New York City / epidemiology
  • Prevalence
  • Regression Analysis
  • Risk Factors
  • Urban Population
  • Vagina / virology
  • Virus Shedding