Treating pruritus. What's new in safe relief of symptoms?

Postgrad Med. 1996 Jan;99(1):173-6, 179-84.


In several cutaneous disorders, pruritus is both the primary symptom and the cause of perpetuating factor. Therefore, one focus of therapy should be on treating pruritus and thereby preventing or aiding in the resolution of skin lesions. Several treatment options are available, including nonpharmacologic methods; use of emollients, tar preparations, and other topical agents; ultraviolet B therapy; and use of oral antihistamines or corticosteroids. A new topical tricyclic agent is now available that adds a promising therapeutic approach.

Publication types

  • Review

MeSH terms

  • Administration, Topical
  • Adrenal Cortex Hormones / administration & dosage
  • Antipruritics / therapeutic use*
  • Doxepin / administration & dosage
  • Histamine H1 Antagonists / therapeutic use
  • Humans
  • Pruritus / drug therapy*
  • Pruritus / etiology
  • Pruritus / physiopathology
  • Pruritus / therapy


  • Adrenal Cortex Hormones
  • Antipruritics
  • Histamine H1 Antagonists
  • Doxepin