Atrial natriuretic peptide and nitric oxide in children with pulmonary hypertension after surgical repair of congenital heart disease

Am J Cardiol. 1996 Jan 1;77(1):102-5. doi: 10.1016/s0002-9149(97)89147-3.


ANP causes pulmonary vasodilation in some children with pulmonary hypertension secondary to congenital heart disease. In a small group of patients, ANP lowered mean pulmonary artery pressure and pulmonary vascular resistance index > 20% without changing systemic vascular resistance index. Inhaled NO is an effective pulmonary vasodilator and is a more selective pulmonary vasodilator than ANP. The utility of ANP may be limited by its nonselective effects as more selective vasodilator agents are available.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Analysis of Variance
  • Atrial Natriuretic Factor / blood*
  • Child
  • Child, Preschool
  • Female
  • Heart Defects, Congenital / blood*
  • Heart Defects, Congenital / complications
  • Heart Defects, Congenital / physiopathology
  • Heart Defects, Congenital / surgery
  • Humans
  • Hypertension, Pulmonary / blood*
  • Hypertension, Pulmonary / etiology
  • Hypertension, Pulmonary / physiopathology
  • Infant
  • Male
  • Nitric Oxide / blood*
  • Vascular Resistance / physiology


  • Nitric Oxide
  • Atrial Natriuretic Factor