Elevated plasma levels of neuropeptide Y in patients with panic disorder

Am J Psychiatry. 1996 Jan;153(1):114-6. doi: 10.1176/ajp.153.1.114.


Objective: Neuropeptide Y is a pancreatic polypeptide closely associated with noradrenergic activity both in the central and peripheral nervous systems. The objective of this study was to assess plasma neuropeptide Y-like immunoreactivity in panic disorder.

Method: Radioimmunoassays were performed in 12 patients with DSM-III-R panic disorder and two groups of normal comparison subjects (N = 22 and N = 16).

Results: Markedly higher plasma neuropeptide Y-like immunoreactivity was found in patients with panic disorder.

Conclusions: Higher plasma neuropeptide Y-like immunoreactivity suggests that this peptide may be implicated in the etiology or expression of symptoms of panic disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Humans
  • Male
  • Neuropeptide Y / blood*
  • Neuropeptide Y / physiology
  • Panic Disorder / blood*
  • Panic Disorder / diagnosis
  • Panic Disorder / physiopathology
  • Psychiatric Status Rating Scales
  • Radioimmunoassay


  • Neuropeptide Y