Congenital muscular dystrophies

Curr Opin Neurol. 1995 Oct;8(5):385-90. doi: 10.1097/00019052-199510000-00011.


Considerable advances in the understanding of congenital muscular dystrophy made during the past year may allow a new clinical classification of this disease. In particular, (1) evidence has accumulated to suggest that a laminin alpha2-chain (alpha2 subunit of laminin-2 or merosin) deficiency causes a type of congenital muscular dystrophy, and (2) it has been postulated that Fukuyama-type congenital muscular dystrophy and Walker-Warburg syndrome (but not Finnish muscle-eye-brain disease) are genetically identical diseases.

Publication types

  • Review

MeSH terms

  • Disease Models, Animal
  • Humans
  • Magnetic Resonance Imaging
  • Microscopy, Electron
  • Muscle, Skeletal / ultrastructure
  • Muscular Dystrophies / congenital
  • Muscular Dystrophies / genetics
  • Muscular Dystrophies / pathology*