Cell cycle. The only way out of mitosis

Curr Biol. 1995 Sep 1;5(9):970-2. doi: 10.1016/s0960-9822(95)00190-4.

Abstract

The ubiquitination and destruction of cyclins provides the way out of mitosis. A multiprotein complex polyubiquitinates cyclin B and promotes the separation of sister chromatids.

Publication types

  • Review

MeSH terms

  • Anaphase / physiology
  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
  • Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
  • Cell Cycle
  • Cell Cycle Proteins / metabolism
  • Cyclins / metabolism*
  • Humans
  • Mitosis*
  • Saccharomyces cerevisiae Proteins*
  • Ubiquitin-Protein Ligase Complexes
  • Ubiquitin-Protein Ligases
  • Ubiquitins / metabolism*

Substances

  • Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
  • Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
  • CDC16 protein, human
  • CDC27 protein, S cerevisiae
  • CDC27 protein, human
  • Cell Cycle Proteins
  • Cyclins
  • Saccharomyces cerevisiae Proteins
  • Ubiquitins
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • Ubiquitin-Protein Ligases