Characterization of the human XPA promoter

Gene. 1995 Dec 12;166(2):341-2. doi: 10.1016/0378-1119(95)00649-4.


We cloned the human xeroderma pigmentosum group A gene (XPA) and characterized the XPA promoter (pXPA) by transient cat expression. The pXPA is extraordinarily weak in human fibroblasts (1% of RSV-LTR) and appears to function without any of the usual promoter elements. Regions containing positive and negative control elements were localized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • DNA-Binding Proteins / genetics*
  • Gene Expression Regulation
  • Molecular Sequence Data
  • Promoter Regions, Genetic*
  • RNA, Messenger / genetics
  • Restriction Mapping
  • Xeroderma Pigmentosum / genetics*
  • Xeroderma Pigmentosum Group A Protein


  • DNA-Binding Proteins
  • RNA, Messenger
  • Xeroderma Pigmentosum Group A Protein

Associated data

  • GENBANK/U10343
  • GENBANK/U10344
  • GENBANK/U10345
  • GENBANK/U10346
  • GENBANK/U10347
  • GENBANK/U16815