Short echo time proton spectroscopy of the brain in HIV infection/AIDS

Magn Reson Imaging. 1995;13(6):871-5. doi: 10.1016/0730-725x(95)00052-i.


Short echo time proton spectra have been acquired from the brains of 30 male homosexual Acquired Immunodeficiency Syndrome (AIDS) patients and 12 age-matched control subjects on a 1.5 T MR system. The acquisition protocol used stimulated acquisition voxel localisation with a voxel size of 8 ml and repeat, echo, and mixing times of 5000, 20, and 30 ms, respectively. A single 25.6-ms Gaussian water suppression pulse was used with 128 spectral acquisitions and the data were eddy current corrected using a water reference. Baseline-corrected spectra were nonlinearly least squares fitted to a model function consisting of Gaussian functions representing the major metabolites reported in short echo proton spectra. Results indicate that the N-acetyl/creatine (NA/Cr) ratio is significantly reduced by 20% in AIDS patients [NA/Cr = 1.91 (0.51)] compared to control subjects [NA/Cr = 2.37 (0.25)] at short echo times.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • AIDS Dementia Complex / metabolism*
  • Adult
  • Brain / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Male