Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus

Neurobiol Aging. Jul-Aug 1995;16(4):591-606. doi: 10.1016/0197-4580(95)00074-o.


The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly correlated with age. By contrast, left and right temporal lobe gray matter volumes, exclusive of the hippocampal measures, each decreased with age (p < 0.01). Volumes of temporal lobe sulcal CSF and the ventricular system (temporal horns and lateral and third ventricles) significantly increased with age. Measures of verbal and nonverbal working memory showed age-related declines and were related to enlargement of the three ventricular regions, which may be indicative of age-related atrophy of the adjacent cortex but not the hippocampus, at least up to age 70 years.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aging / pathology*
  • Aging / physiology
  • Analysis of Variance
  • Atrophy
  • Cerebral Ventricles / pathology
  • Hippocampus / pathology*
  • Humans
  • Least-Squares Analysis
  • Magnetic Resonance Imaging*
  • Male
  • Memory*
  • Mental Recall
  • Middle Aged
  • Nerve Tissue / pathology
  • Neuropsychological Tests
  • Temporal Lobe / pathology*
  • Verbal Learning