Clinical features and pathophysiologic mechanisms of postherpetic neuralgia

Neurology. 1995 Dec;45(12 Suppl 8):S54-5. doi: 10.1212/wnl.45.12_suppl_8.s54.


Postherpetic neuralgia is an unfortunate aftermath of shingles, and is most likely to develop, and most persistent, in elderly patients. Pain, allodynia, and sensory loss in the affected dermatome are the cardinal manifestations of the disorder. The pathophysiology of postherpetic neuralgia is not well known, but recent observations suggest multiple changes in the afferent pathways at both peripheral and central nervous system levels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Herpes Zoster / complications
  • Herpes Zoster / physiopathology*
  • Humans
  • Neuralgia / etiology
  • Neuralgia / physiopathology*
  • Time Factors