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, 45 (12 Suppl 8), S66-8

Dextromethorphan Shows Efficacy in Experimental Pain (Nociception) and Opioid Tolerance

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Dextromethorphan Shows Efficacy in Experimental Pain (Nociception) and Opioid Tolerance

K J Elliott et al. Neurology.

Abstract

The oral antitussive dextromethorphan is a clinically available N-methyl-D-aspartate receptor antagonist. Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models. These data suggest that dextromethorphan should be evaluated in a controlled clinical trial for analgesic efficacy in zoster-associated neuralgia.

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