Bilateral acute angle-closure glaucoma after dexfenfluramine treatment

Ophthalmologica. 1995;209(4):223-4. doi: 10.1159/000310619.


We report the case of a patient with narrow angles who had an attack of bilateral acute angle-closure glaucoma precipitated by dexfenfluramine, a serotoninergic drug developed for appetite suppression. Although the exact mechanism remains uncertain, the pupillary block observed in our case may be the result of the serotoninergic or indirect parasympatholytic properties of the drug on the iris sphincter muscle. Serotonergic psychoactive drugs should be prescribed cautiously in patients with known narrow angles and should be monitored by an ophthalmologist.

Publication types

  • Case Reports

MeSH terms

  • Appetite / drug effects
  • Appetite Depressants / adverse effects*
  • Female
  • Fenfluramine / adverse effects*
  • Glaucoma, Angle-Closure / chemically induced*
  • Glaucoma, Angle-Closure / surgery
  • Humans
  • Intraocular Pressure
  • Iris / drug effects
  • Iris / surgery
  • Laser Therapy
  • Middle Aged
  • Muscle, Smooth / drug effects
  • Serotonin Agents / adverse effects*
  • Visual Acuity


  • Appetite Depressants
  • Serotonin Agents
  • Fenfluramine