Efficient removal of albumin-bound furancarboxylic acid by protein-leaking hemodialysis

Am J Nephrol. 1995;15(6):463-7. doi: 10.1159/000168887.

Abstract

Furancarboxylic acid (3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, CMPF), an inhibitor of erythropoiesis, cannot be removed by conventional hemodialysis due to its strong albumin binding, resulting in its accumulation in uremic serum. We used protein-leaking hemodialysis with BK-F dialyzers in 8 uremic patients for 4 months to determine its effect on the serum levels of CMPF. Pre-hemodialysis serum levels of CMPF significantly decreased to about 50% after 4 months by protein-leaking hemodialysis, while those of BUN and serum creatinine did not change significantly. Pre-hemodialysis hematocrit and hemoglobin levels significantly increased by protein-leaking hemodialysis. These results indicate that protein-leaking hemodialysis reduces serum levels of albumin-bound CMPF and improves anemia.

MeSH terms

  • Adult
  • Anemia / etiology
  • Anemia / prevention & control
  • Blood Urea Nitrogen
  • Chromatography, High Pressure Liquid
  • Creatinine / blood
  • Female
  • Furans / blood*
  • Hematocrit
  • Hemoglobins / metabolism
  • Humans
  • Male
  • Membranes, Artificial
  • Middle Aged
  • Propionates / blood*
  • Protein Binding
  • Renal Dialysis* / adverse effects
  • Renal Dialysis* / methods
  • Serum Albumin / metabolism*
  • Uremia / blood
  • Uremia / therapy*

Substances

  • Furans
  • Hemoglobins
  • Membranes, Artificial
  • Propionates
  • Serum Albumin
  • 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid
  • Creatinine