The coexistence of systemic sclerosis and rheumatoid arthritis in five patients. Clinical and immunogenetic features suggest a distinct entity

Arthritis Rheum. 1996 Jan;39(1):152-6. doi: 10.1002/art.1780390121.


To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DBQ1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Arthritis, Rheumatoid / blood
  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / immunology
  • Female
  • HLA-DQ Antigens / blood
  • HLA-DR Antigens / blood
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Scleroderma, Systemic / blood
  • Scleroderma, Systemic / complications*
  • Scleroderma, Systemic / immunology


  • HLA-DQ Antigens
  • HLA-DR Antigens