EBV-associated lymphoproliferative syndrome with a distinct 69 base-pair deletion in the LMP-1 oncogene

Br J Haematol. 1995 Dec;91(4):938-40. doi: 10.1111/j.1365-2141.1995.tb05416.x.

Abstract

We describe an immunocompetent 12-year-old boy with chronic EBV infection and lymphoid interstitial pneumonitis. Lymph node biopsies showed effacement of the architecture with polymorphic cellular infiltrates, consisting predominantly of T cells and natural killer cells. No clonal rearrangement of TCR or immunoglobulin genes was seen. DNA was extracted from hilar lymph nodes; sequencing of the carboxy terminal region of the latent membrane protein 1 (LMP-1) oncogene revealed a 69 base-pair deletion and four point mutations. Immunosuppressive treatment with prednisone and cyclosporine reversed the lymphadenopathy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Composition
  • Base Sequence
  • Child
  • Cyclosporine / therapeutic use
  • DNA Primers / genetics
  • Electrophoresis, Agar Gel
  • Gene Deletion*
  • Herpesviridae Infections / drug therapy
  • Herpesviridae Infections / genetics*
  • Herpesviridae Infections / pathology
  • Herpesvirus 4, Human / immunology*
  • Humans
  • Lung Diseases, Interstitial / drug therapy
  • Lung Diseases, Interstitial / genetics
  • Lung Diseases, Interstitial / pathology
  • Lymph Nodes / pathology
  • Male
  • Molecular Sequence Data
  • Point Mutation
  • Polymerase Chain Reaction
  • Prednisolone / therapeutic use
  • Tumor Virus Infections / drug therapy
  • Tumor Virus Infections / genetics*
  • Tumor Virus Infections / pathology
  • Viral Matrix Proteins / genetics*

Substances

  • DNA Primers
  • EBV-associated membrane antigen, Epstein-Barr virus
  • Viral Matrix Proteins
  • Cyclosporine
  • Prednisolone