[Possibilities of the use of MR tomography-based cerebral blood volume maps in the diagnosis of brain tumors]

Rofo. 1995 Dec;163(6):484-9. doi: 10.1055/s-2007-1016034.
[Article in German]


Purpose: Today contrast enhanced MR imaging is a reliable method for detecting mostly distinguishing between different histological types of tumours. In this study we use a MR-based method to measure the regional cerebral blood volume (rCBV). Using this technique we try to judge the grading and vitality of the tumours.

Methods: 26 patients with various types of brain tumours were examined. To calculate rCBV-maps of one slice, low-dosed Gd-DTPA was injected as a bolus. Using the relaxation effect the obtained signal intensity-time curves were converted pixel-wise into rCBV images. For the tumours rCBV-ratios were calculated relative to the corresponding area in the contralateral hemisphere.

Results: In the investigated group all tumours were detected on the basis of a raised rCBV-ratio. Since only vital parts of the tumour are perfused, the rCBV maps may be used to determine the place of biopsy.

Conclusions: The differential diagnosis of all histological tumour types was not possible on the basis of rCBV values. Distinction between low grade and high grade gliomas was also not significant. However, a low grade glioma can be excluded if the morphological images definitely indicate an astrocytoma and if the rCBV-ratio was higher than 2.

Publication types

  • Case Reports
  • Comparative Study
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Astrocytoma / diagnosis
  • Blood Volume
  • Brain / blood supply*
  • Brain Neoplasms / diagnosis*
  • Diagnosis, Differential
  • Female
  • Glioblastoma / diagnosis
  • Humans
  • Lymphoma / diagnosis
  • Magnetic Resonance Imaging*
  • Male
  • Meningeal Neoplasms / diagnosis
  • Meningioma / diagnosis
  • Middle Aged
  • Oligodendroglioma / diagnosis