Dopamine release in the medial preoptic area during male copulatory behavior in rats

Brain Res. 1995 Sep 18;692(1-2):66-70. doi: 10.1016/0006-8993(95)00656-b.


In vivo microdialysis was employed to measure the extracellular concentrations of dopamine (DA) in the medial preoptic area (MPOA) of rats during male sexual activity to look for a correlation with sexual activity. During copulation, the concentration of DA in the MPOA was significantly increased. A significant difference was detected in changes of DA between copulators and non-copulators. These findings were consistent with the assertion that DA neuron activity in the MPOA facilities male copulatory behavior.

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Copulation / physiology*
  • Dopamine / metabolism*
  • Ejaculation / physiology
  • Extracellular Space / metabolism
  • Female
  • Homovanillic Acid / metabolism
  • Male
  • Microdialysis
  • Preoptic Area / metabolism*
  • Rats
  • Rats, Wistar


  • 3,4-Dihydroxyphenylacetic Acid
  • Dopamine
  • Homovanillic Acid