Stimulation of A1 adenosine receptors mimics the electroencephalographic effects of sleep deprivation

Brain Res. 1995 Sep 18;692(1-2):79-85. doi: 10.1016/0006-8993(95)00590-m.


N6-Cyclopentyladenosine (CPA), an A1 adenosine receptor agonist, increased EEG slow-wave activity in nonREM sleep when administered either systemically (0.1-3 mg/kg) or intracerebroventricularly (3.5-10 micrograms) in the rat. The power spectrum of EEG changes (as calculated by Fourier analysis) matched that produced by total sleep deprivation in the rat. The effects of CPA on the nonREM-sleep EEG were dose-dependent. These findings suggest that adenosine is an endogenous mediator of sleep-deprivation induced increases in EEG slow-wave activity, and therefore that increased adenosine release is a concomitant of accumulation of sleep need and may be involved in homeostatic feedback control of sleep expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine / administration & dosage
  • Adenosine / analogs & derivatives*
  • Adenosine / pharmacology
  • Adenosine / physiology
  • Animals
  • Behavior, Animal / drug effects
  • Dose-Response Relationship, Drug
  • Electroencephalography / drug effects*
  • Fourier Analysis
  • Injections, Intraventricular
  • Male
  • Purinergic P1 Receptor Agonists*
  • Rats
  • Rats, Wistar
  • Sleep Deprivation / physiology*
  • Sleep, REM / physiology


  • Purinergic P1 Receptor Agonists
  • N(6)-cyclopentyladenosine
  • Adenosine