Radiation therapy for age-related subfoveal choroidal neovascular membranes. A pilot study

Doc Ophthalmol. 1995;90(1):67-74. doi: 10.1007/BF01203296.


In this pilot study the effect of radiation therapy on subfoveal CNV membranes associated with age-related macular degeneration was evaluated. Four groups of 10 patients were treated with external beam radiotherapy (16 MV photons) on an area of 1 cm2 (macular region) using a lens-sparing technique and total dose of 8 to 24 Gy. The first group received 8 Gy in a single fraction. In this group only 30% had a stable visual acuity and a stable FA after 18 months follow-up. In 50% of patients in group 2 (12 Gy) and 40% of patients in group 3 (18 Gy) the visual acuity and FA appearance remained stable after 18 months of follow-up. In the last group (24 Gy) 80% of patients had a stable visual acuity and FA appearance after 12 months follow-up. Comparison of these findings with the natural history data of subfoveal age-related CNV, suggests a beneficial effect of radiation therapy with a total dose of 12 Gy or more on the progression of CNV membranes.

Publication types

  • Case Reports
  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Aged
  • Choroid / blood supply*
  • Choroid / radiation effects
  • Fluorescein Angiography
  • Follow-Up Studies
  • Fovea Centralis / radiation effects*
  • Fundus Oculi
  • Humans
  • Macular Degeneration / complications*
  • Male
  • Membranes
  • Neovascularization, Pathologic / etiology
  • Neovascularization, Pathologic / radiotherapy*
  • Pilot Projects
  • Radiotherapy Dosage
  • Visual Acuity