Bilateral subthalamic nucleus stimulation for severe Parkinson's disease

Mov Disord. 1995 Sep;10(5):672-4. doi: 10.1002/mds.870100523.


Subthalamic nucleus (STN) lesions or high-frequency stimulations could improve parkinsonian symptoms in monkeys treated by MPTP. We have applied the procedure of chronic stimulation to the STN in severely disabled parkinsonian patients. This article presents the case of the first patient operated on bilaterally. Bilateral STN stimulation has greatly improved akinesia and rigidity. The benefit was maintained < or = 15 months after surgery. Unilateral stimulation induced motor effects mainly in contralateral limbs. Further studies are needed to evaluate the value of this procedure in the treatment of Parkinson's disease.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiparkinson Agents / administration & dosage
  • Antiparkinson Agents / therapeutic use
  • Dose-Response Relationship, Drug
  • Electric Stimulation*
  • Electrodes, Implanted
  • Functional Laterality*
  • Humans
  • Levodopa / administration & dosage
  • Levodopa / therapeutic use
  • Male
  • Middle Aged
  • Parkinson Disease* / drug therapy
  • Parkinson Disease* / physiopathology
  • Parkinson Disease* / surgery
  • Severity of Illness Index
  • Thalamic Nuclei*


  • Antiparkinson Agents
  • Levodopa