The Management of Gout

N Engl J Med. 1996 Feb 15;334(7):445-51. doi: 10.1056/NEJM199602153340707.

Abstract

We now have sufficient knowledge to be able to identify the factors contributing to hyperuricemia in most patients with gout. Some of these factors, such as obesity, a high-purine diet, regular alcohol consumption, and diuretic therapy, may be correctable. In patients with persistent hyperuricemia, regular medication should lower the serum urate concentration to an optimal level. The continuing challenge is to educate patients about correctable factors and the importance of regular medication and ensure their compliance so that attacks of gout do not recur.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Anti-Inflammatory Agents / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Colchicine / therapeutic use
  • Diet
  • Gout / drug therapy
  • Gout / prevention & control
  • Gout / therapy*
  • Gout Suppressants / therapeutic use*
  • Humans
  • Purines / administration & dosage
  • Steroids
  • Uric Acid / blood
  • Uricosuric Agents / therapeutic use
  • Xanthine Oxidase / antagonists & inhibitors

Substances

  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Gout Suppressants
  • Purines
  • Steroids
  • Uricosuric Agents
  • Uric Acid
  • Xanthine Oxidase
  • Colchicine