Principles of protein-protein interactions

Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):13-20. doi: 10.1073/pnas.93.1.13.

Abstract

This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Antibody Complex / chemistry
  • Crystallography, X-Ray
  • Humans
  • Hydrogen Bonding
  • Macromolecular Substances
  • Protein Binding*
  • Protein Conformation
  • Protein Structure, Secondary
  • Proteins / chemistry*
  • Solubility
  • Structure-Activity Relationship

Substances

  • Antigen-Antibody Complex
  • Macromolecular Substances
  • Proteins