Recombinant human DNase in management of lobar atelectasis due to retained secretions

B A Touleimat; C S Conoscenti; J M Fine

doi:10.1136/thx.50.12.1319

Recombinant human DNase in management of lobar atelectasis due to retained secretions

Thorax. 1995 Dec;50(12):1319-21; discussion 1323. doi: 10.1136/thx.50.12.1319.

Authors

B A Touleimat¹, C S Conoscenti, J M Fine

Affiliation

¹ Section of Pulmonary and Critical Care Medicine, Norwalk Hospital, Connecticut 06856, USA.

Abstract

Recombinant human deoxyribonuclease (rhDNase) is an agent which reduces the viscoelasticity of purulent sputum. Two cases are reported in which rhDNase was utilised for the management of lobar atelectasis due to retained purulent secretions.

Publication types

Case Reports

MeSH terms

Adult
Deoxyribonuclease I / therapeutic use*
Expectorants / therapeutic use*
Humans
Instillation, Drug
Male
Recombinant Proteins / therapeutic use
Respiratory Distress Syndrome / drug therapy*
Sputum / drug effects

Substances

Expectorants
Recombinant Proteins
DNASE1 protein, human
Deoxyribonuclease I