Recombinant human DNase in management of lobar atelectasis due to retained secretions

Thorax. 1995 Dec;50(12):1319-21; discussion 1323. doi: 10.1136/thx.50.12.1319.


Recombinant human deoxyribonuclease (rhDNase) is an agent which reduces the viscoelasticity of purulent sputum. Two cases are reported in which rhDNase was utilised for the management of lobar atelectasis due to retained purulent secretions.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Deoxyribonuclease I / therapeutic use*
  • Expectorants / therapeutic use*
  • Humans
  • Instillation, Drug
  • Male
  • Recombinant Proteins / therapeutic use
  • Respiratory Distress Syndrome / drug therapy*
  • Sputum / drug effects


  • Expectorants
  • Recombinant Proteins
  • DNASE1 protein, human
  • Deoxyribonuclease I