GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast

Yeast. 1995 Oct;11(13):1311-6. doi: 10.1002/yea.320111312.


While sequencing a region of chromosome IV adjacent to the checkpoint gene MEC3, we identified a gene we call GUF1 (GTPase of Unknown Function), which predicts a 586 amino acid GTPase of the elongation factor-type class. The predicted Guf1p protein bears striking sequence similarity to both LepA from Escherichia coli (43% identical) and LK1236.1 from Caenorhabditis elegans (42% identical). Analysis of both a guf1 delta deletion and a putative constitutive-activating mutant (GUF1HG) revealed that GUF1 is not essential nor did mutant cells reveal any marked phenotype.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Biological Evolution
  • Conserved Sequence
  • GTP Phosphohydrolases / genetics*
  • Genes, Fungal*
  • Molecular Sequence Data
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics*


  • GTP Phosphohydrolases

Associated data

  • GENBANK/U22360