Treatment of migraine headache after ocular surgery with intravenous metoclopramide hydrochloride

Am J Ophthalmol. 1996 Jan;121(1):96-7. doi: 10.1016/s0002-9394(14)70542-2.


Purpose: To alert ophthalmologists that prolonged or severe postoperative periocular pain and nausea may be caused by migraine.

Methods: We examined two patients who had a history of migraine and had severe episodes of prolonged periocular pain and nausea after ocular procedures. Both patients experienced symptoms similar to their previous migraine attacks. In neither was pain alleviated by routine analgesics.

Results: Each patient had relief of symptoms within two minutes after intravenous delivery of metoclopramide hydrochloride.

Conclusions: Ophthalmologists should consider the diagnosis of postoperative migraine in similar patients and provide specific therapy such as intravenous metoclopramide hydrochloride.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cataract Extraction / adverse effects*
  • Dopamine Antagonists / administration & dosage
  • Dopamine Antagonists / therapeutic use*
  • Female
  • Humans
  • Injections, Intravenous
  • Lenses, Intraocular
  • Male
  • Metoclopramide / administration & dosage
  • Metoclopramide / therapeutic use*
  • Migraine Disorders / drug therapy*
  • Migraine Disorders / etiology
  • Nausea / drug therapy
  • Nausea / etiology
  • Pain, Postoperative / drug therapy*
  • Pain, Postoperative / etiology
  • Retinal Detachment / surgery
  • Retinal Hemorrhage / surgery
  • Vitrectomy / adverse effects*


  • Dopamine Antagonists
  • Metoclopramide