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Comparative Study
. 1995 Oct;13(3):205-8.
doi: 10.1016/0887-8994(95)00159-d.

Reduced N-acetylaspartate in the Brain Observed on in Vivo Proton Magnetic Resonance Spectroscopy in Patients With Mental Retardation

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Comparative Study

Reduced N-acetylaspartate in the Brain Observed on in Vivo Proton Magnetic Resonance Spectroscopy in Patients With Mental Retardation

T Hashimoto et al. Pediatr Neurol. .

Abstract

Volume-selective proton magnetic resonance spectroscopy (1H-MRS) of the brain was performed with a 1.5T magnet in 28 patients with unclassified mental retardation (MR) and in 25 age-matched healthy children. Peaks of N-acetylaspartate (NAA), choline (Cho), and creatine (Cr), but not of lactate, were observed in both groups on 1H-MRS. In all our subjects of this age range, 1H-MRS revealed an increase with advancing age in the ratio of NAA/Cho (P = .0031), but no developmental change in the NAA/Cr and Cho/Cr ratios. The NAA/Cho ratio was lower in patients with MR than in controls (P = .0016). The NAA/Cr ratio tended to be lower in the MR group, and the Cho/Cr ratio did not differ between patients with MR and controls. These results suggest that in patients with MR, NAA decreases and a disorder and/or dysfunction of neurons in the brain exists.

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