Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells

Mech Dev. 1995 Sep;53(1):73-85. doi: 10.1016/0925-4773(95)00425-4.


The Notch pathway is thought to define an evolutionarily conserved signaling mechanism that regulates the differentiation of immature cells through cells interactions. We have examined the expression of the Notch-1 receptor, the central element of this pathway, in the developing rat retina, where cell-fate choices depend upon a series of local cell interactions. Notch-1 immunoreactivity is associated with differentiating cells at different stages of retinal neurogenesis, suggesting that Notch-1 may play a role in the successive cell-fate determination which governs retinal development. In addition, the Notch-1 immunoreactivity is detected in nuclei of postmitotic, differentiated neurons of the adult retina. Our observations raise the possibility that besides its role in the differentiation of immature cell populations Notch-1 activity may also be involved in the maintenance of the differentiated state.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Base Sequence
  • Cell Differentiation / physiology
  • Cellular Senescence / physiology
  • Conserved Sequence*
  • Cross Reactions
  • Humans
  • Membrane Proteins / analysis
  • Membrane Proteins / biosynthesis*
  • Membrane Proteins / immunology
  • Middle Aged
  • Mitosis / physiology
  • Molecular Sequence Data
  • Morphogenesis
  • Nerve Tissue Proteins / analysis
  • Nerve Tissue Proteins / biosynthesis*
  • Nervous System / cytology
  • Nervous System / embryology*
  • Neurons / metabolism
  • Rats
  • Receptor, Notch1
  • Receptors, Cell Surface*
  • Retina / embryology*
  • Subcellular Fractions / chemistry
  • Transcription Factors*


  • Antibodies, Monoclonal
  • Membrane Proteins
  • NOTCH1 protein, human
  • Nerve Tissue Proteins
  • Notch1 protein, rat
  • Receptor, Notch1
  • Receptors, Cell Surface
  • Transcription Factors