The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease

J Neuropsychiatry Clin Neurosci. Fall 1995;7(4):476-84. doi: 10.1176/jnp.7.4.476.


Cognitive and noncognitive psychiatric symptoms were systematically evaluated in 21 patients with Alzheimer's disease by using the Neurobehavioral Rating Scale. Regional cerebral metabolic activity was measured in each patient by [18F]fluorodeoxyglucose PET. Significant correlations emerged between global cortical metabolic activity and the Agitation/Disinhibition factor score, Cognition factor score, and total score. Relationships between noncognitive symptoms and metabolic activity were regionally specific, with significant correlations between Agitation/Disinhibition factor score and metabolism in the frontal and temporal lobes, between Psychosis factor score and metabolism in the frontal lobe, and between Anxiety/Depression factor score and metabolism in the parietal lobe. These results suggest that psychiatric symptoms are fundamental expressions of the cortical dysfunction of Alzheimer's disease.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnostic imaging*
  • Alzheimer Disease / psychology
  • Arousal / physiology
  • Blood Glucose / metabolism*
  • Brain Mapping
  • Cerebral Cortex / diagnostic imaging*
  • Deoxyglucose / analogs & derivatives
  • Deoxyglucose / metabolism
  • Energy Metabolism / physiology*
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Mental Status Schedule
  • Middle Aged
  • Neuropsychological Tests
  • Tomography, Emission-Computed*


  • Blood Glucose
  • Fluorodeoxyglucose F18
  • Deoxyglucose