Mazindol treatment for cocaine dependence

Drug Alcohol Depend. 1995 Oct;39(3):245-52. doi: 10.1016/0376-8716(95)01174-4.


This double-blind placebo-controlled treatment study tested the efficacy of mazindol in currently cocaine-dependent out-patients. Forty-three patients were randomized to mazindol (2 mg QD) vs. placebo treatment for 6 weeks. All patients received weekly group counseling. Patients improved with respect to objective (urine toxicology) and subjective (self-report of times used, dollars spent, craving, etc.) measures. There was no response difference between patients treated with mazindol and those who received placebo.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Central Nervous System Stimulants / adverse effects
  • Central Nervous System Stimulants / therapeutic use*
  • Cocaine* / adverse effects
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Mazindol / adverse effects
  • Mazindol / therapeutic use*
  • Neurologic Examination / drug effects
  • Substance Abuse Detection
  • Substance Withdrawal Syndrome / rehabilitation
  • Substance-Related Disorders / rehabilitation*


  • Central Nervous System Stimulants
  • Mazindol
  • Cocaine