A novel site of DNA amplification on chromosome 1p32-33 in a rhabdomyosarcoma revealed by comparative genomic hybridization

Hum Genet. 1996 Jan;97(1):87-90. doi: 10.1007/BF00218839.

Abstract

Cytogenetic analysis of a human embryonal rhabdomyosarcoma revealed a near-diploid karyotype with structural chromosome aberrations not involving the typical rearrangements of rhabdomyosarcomas, plus a large number of double minutes. Comparative genomic hybridization revealed a previously undescribed site of DNA amplification on the short arm of chromosome 1 (band 1p32-33).

Publication types

  • Case Reports

MeSH terms

  • Child
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • DNA Probes
  • DNA, Neoplasm / genetics*
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Muscle Neoplasms / genetics*
  • Muscle Neoplasms / pathology
  • Rhabdomyosarcoma / genetics*
  • Rhabdomyosarcoma / pathology

Substances

  • DNA Probes
  • DNA, Neoplasm