Role of prostaglandin synthesis inhibitors on chemically induced seizures

Indian J Exp Biol. 1995 Sep;33(9):677-81.

Abstract

The study was conducted to find out the possible role of prostaglandin synthesis inhibitors on different parameters of chemically induced seizures in albino mice. The results suggest that prostaglandins have a proconvulsant activity. Augmentation of central dopamine and serotonin levels is partly responsible for the inhibitory effect of prostaglandin synthesis inhibitors on chemically induced seizures.

MeSH terms

  • Animals
  • Cyclooxygenase Inhibitors / therapeutic use*
  • Drug Interactions
  • Female
  • Male
  • Mice
  • Seizures / chemically induced
  • Seizures / drug therapy*

Substances

  • Cyclooxygenase Inhibitors