Detection of neopterin, interleukin-6 and acute-phase proteins as parameters of potential monocyte activation in preoperative patients

Infection. 1995 Sep-Oct;23(5):263-6. doi: 10.1007/BF01716282.

Abstract

Monocytes play a key role in the immune response to trauma and infection. Is monocyte function already altered before surgery in terms of cell activation? On admission, serum neopterin was at or above 9 nmol/l in 50.2% and serum IL-6 was detectable (> 4 pg/ml) in 10.5% of 227 patients electively undergoing major abdominal surgery. Mean values of CRP (0.8 vs. 3.6), alpha-1-antitrypsin (267 vs. 376), albumin (4.0 vs. 3.5), prealbumin (27.0 vs. 17.9, all at p < 0.01) were significantly different in patients with or without monocyte activation (neopterin > 9 nmol/l and IL-6 > 4 pg/ml). There was a significant correlation between neopterin and the acute phase proteins (all at p < 0.01). The data reflect a "primed" state at least of some parts of the immune system in a subgroup of preoperative patients potentially affecting their response to surgical trauma and bacterial contamination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdomen / surgery*
  • Acute-Phase Proteins / analysis*
  • Adult
  • Aged
  • Aged, 80 and over
  • Biopterin / analogs & derivatives*
  • Biopterin / blood
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Leukocyte Count
  • Male
  • Middle Aged
  • Monocytes / immunology*
  • Neopterin
  • Preoperative Care*

Substances

  • Acute-Phase Proteins
  • Interleukin-6
  • Biopterin
  • Neopterin