Potentiation of ionophorous anticoccidials with dihydroquinolines: compatibility of lasalocid and semduramicin with duokvin

Int J Parasitol. 1995 Oct;25(10):1243-5. doi: 10.1016/0020-7519(95)00040-9.


Three battery tests were conducted to reveal whether or not there is an interaction between the new dihydroquinoline antioxidant, duokvin and lasalocid or the new anticoccidial, semduramicin, similar to that observed with some other ionophorous anticoccidials. In terms of body weight gain, no significant difference due to toxic interaction between duokvin and any dose of lasalocid or semduramicin was detected in chickens experimentally infected with oocysts of Eimeria tenella and E. mitis. Anticoccidial efficacy at reduced doses of both lasalocid and semduramicin in combination with duokvin showed numerical improvement; however, this again proved to be insignificant. The lack of incompatibility of this antioxidant with lasalocid or semduramicin allows their simultaneous administration on the one hand, but it fails to enable a substantial reduction of the chemoprophylactic concentration of anticoccidials in the broiler ration on the other.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chickens*
  • Coccidiosis / drug therapy
  • Coccidiosis / veterinary*
  • Coccidiostats / pharmacology*
  • Drug Interactions
  • Eimeria / drug effects
  • Ionophores / pharmacology
  • Lasalocid / pharmacology*
  • Nigericin / analogs & derivatives*
  • Nigericin / pharmacology
  • Poultry Diseases / drug therapy*
  • Quinolines / pharmacology*


  • Coccidiostats
  • Ionophores
  • Quinolines
  • duokvin
  • semduramicin
  • Nigericin
  • Lasalocid