Rakicidins, new cytotoxic lipopeptides from Micromonospora sp. fermentation, isolation and characterization

J Antibiot (Tokyo). 1995 Dec;48(12):1446-52. doi: 10.7164/antibiotics.48.1446.

Abstract

The new cytotoxic agents rakicidins A and B were isolated from cultured broth of a Micromonospora sp. Spectroscopic and amino acid analysis has shown that rakicidin A is a new cyclic lipopeptide, consisting of 4-amino-penta-2,4-dienoic acid, 3-hydroxy-2,4,16-trimethyl-heptadecanoic acid, sarcosine, and 3-hydroxyasparagine. Rakicidin B differs by one methylene group in the lipid side chain. These compounds exhibited cytotoxicity against the M109 cell line.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / isolation & purification
  • Antibiotics, Antineoplastic / pharmacology*
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Fermentation
  • Lipopeptides
  • Mice
  • Micromonospora / metabolism*
  • Molecular Structure
  • Peptides, Cyclic / biosynthesis
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification
  • Peptides, Cyclic / pharmacology
  • Spectrum Analysis
  • Tumor Cells, Cultured

Substances

  • Antibiotics, Antineoplastic
  • Lipopeptides
  • Peptides, Cyclic
  • rakicidins