The role of MIP-1 alpha in inflammation and hematopoiesis

J Leukoc Biol. 1996 Jan;59(1):61-6. doi: 10.1002/jlb.59.1.61.


Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a member of the C-C subfamily of chemokines, a large superfamily of low-molecular weight, inducible proteins that exhibit a variety of proinflammatory activities in vitro including leukocyte chemotaxis. MIP-1 alpha is a particularly interesting chemokine, because in addition to its proinflammatory activities, it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo. Here, the biologic properties of MIP-1 alpha are reviewed in light of recent data on mice homozygous for a disruption of the MIP-1 alpha gene. The MIP-1 alpha null mice have no overt abnormalities of peripheral blood or bone marrow cells, indicating that MIP-1 alpha is not necessary for normal hematopoiesis. However, the MIP-1 alpha null mice have a mice have a reduced inflammatory reduced inflammatory response to influenza virus and are resistant to coxsackievirus-induced myocarditis. These data demonstrate that MIP-1 alpha is required for a normal inflammatory response to these viruses. Agent that inhibit the action of MIP-1 alpha may therefore prove useful for controlling inflammation in these and other settings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chemokine CCL3
  • Chemokine CCL4
  • Hematopoiesis / physiology*
  • Humans
  • Inflammation / physiopathology*
  • Macrophage Inflammatory Proteins
  • Mice
  • Monokines / physiology*


  • Chemokine CCL3
  • Chemokine CCL4
  • Macrophage Inflammatory Proteins
  • Monokines