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, 11 (3), 491-9

Inhibition of Initiation, Elongation, and Termination of Eukaryotic Protein Synthesis by Trichothecene Fungal Toxins

Inhibition of Initiation, Elongation, and Termination of Eukaryotic Protein Synthesis by Trichothecene Fungal Toxins

E Cundliffe et al. Antimicrob Agents Chemother.

Abstract

The 12,13-epoxytrichothecenes, specific inhibitors of protein synthesis in eukaryotes, can be subdivided further in terms of their mode of action. In addition to the I-type (initiation inhibitors) and E-types (elongation inhibitors), we found that some E-types apparently exhibit inhibition of chain termination at low concentrations. The nature of substituents on C4 may determine the type of inhibitory activity observed.

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References

    1. Biochem J. 1976 Jan 15;154(1):171-8 - PubMed
    1. J Biol Chem. 1973 Nov 25;248(22):7970-2 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Jan;71(1):30-4 - PubMed
    1. FEBS Lett. 1975 Jan 15;50(1):8-12 - PubMed
    1. J Cell Physiol. 1973 Aug;82(1):121-8 - PubMed

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