Can interstitial pneumonia as the sole presentation of collagen vascular diseases be differentiated from idiopathic interstitial pneumonia?

Respiration. 1995;62(5):248-51. doi: 10.1159/000196457.


We prospectively followed 68 patients diagnosed as idiopathic interstitial pneumonia (IIP) over a period of 1-11 years. Thirteen patients (19%) subsequently developed systemic manifestations of collagen vascular diseases (CVD) and were diagnosed as having had interstitial pneumonia as the sole presentation of CVD (CVD-IP). Compared with the 55 IIP patients, the 13 CVD-IP patients were relatively younger, predominantly female, and had a lower incidence of dust inhalation in their history. They also had a higher erythrocyte sedimentation rate, higher incidence of the x-ray finding of discoid atelectasis in the lower lung fields, and a better prognosis than the IIP patients. However, these features did not clearly distinguish the two groups. We conclude that the patients clinically and/or histologically defined as suffering from IIP cannot be distinguished from CVD-IP patients before systemic signs of CVD appear in the latter group.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Collagen Diseases / blood
  • Collagen Diseases / diagnosis*
  • Collagen Diseases / physiopathology
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Humans
  • Lung Diseases, Interstitial / blood
  • Lung Diseases, Interstitial / diagnosis*
  • Lung Diseases, Interstitial / physiopathology
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Vascular Diseases / blood
  • Vascular Diseases / diagnosis*
  • Vascular Diseases / physiopathology