Studies With an Artificial Endocrine Pancreas

Arch Intern Med. 1977 May;137(5):639-49.

Abstract

Short-term studies with an artificial endocrine pancreas have provided insights into the pathophysiology of diabetes and demonstrated the ability of such a system to restore and maintain glucose homeostasis in human subjects given either their usual diet, a 50 gm oral glucose tolerance test, or a moderate level of physical exercise. Animals were used to demonstrate that a peripheral route of insulin delivery by the artificial pancreas is equivalent to the portal route.

MeSH terms

  • Animals
  • Artificial Organs*
  • Blood Glucose / metabolism
  • Diabetes Mellitus / physiopathology*
  • Disease Models, Animal
  • Dogs
  • Fatty Acids, Nonesterified / blood
  • Glucagon / metabolism
  • Glucose Tolerance Test / methods
  • Homeostasis
  • Humans
  • Insulin / administration & dosage
  • Pancreas / physiopathology*
  • Physical Exertion

Substances

  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Insulin
  • Glucagon