White Matter Microglia Produce Membrane-Type Matrix Metalloprotease, an Activator of Gelatinase A, in Human Brain Tissues

Acta Neuropathol. 1995;90(5):421-4. doi: 10.1007/BF00294800.


Membrane-type matrix metalloprotease (MT-MMP) is an activator of gelatinase A (MMP-2), which has previously been found in carcinoma cells. We examined non-neurological and Alzheimer's disease brain tissues for MT-MMP by immunohistochemistry and in situ hybridization. The anti-MT-MMP antibodies gave positive staining of brain microglial cells in all the brain tissues. Positively stained microglia were found only in the white matter. The cells producing MT-MMP protein were also shown to be white matter microglia. These results provide further evidence that activated gelatinase A, which may be a processing enzyme for degradation of beta-amyloid protein, may be produced in white matter microglia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / enzymology*
  • Base Sequence
  • Blotting, Western
  • Brain / enzymology*
  • Female
  • Gelatinases / metabolism*
  • Humans
  • In Situ Hybridization
  • Male
  • Matrix Metalloproteinase 2
  • Metalloendopeptidases / metabolism*
  • Microglia / enzymology*
  • Middle Aged
  • Molecular Sequence Data


  • Gelatinases
  • Metalloendopeptidases
  • Matrix Metalloproteinase 2