Reliability of sequential naloxone challenge tests

Am J Drug Alcohol Abuse. 1995 Nov;21(4):453-67. doi: 10.3109/00952999509002710.

Abstract

To determine the reliability of serial naloxone challenges, five heroin addicts stabilized on methadone were given 0.2 mg naloxone intravenously on three consecutive days. Two-factor ANOVA revealed that the between-subjects effect accounted for at least 63% of the variance in each of the dependent measures, and the effect of challenge number for at most 22%. Withdrawal tended to be slightly more severe for the first challenge. Intraclass correlation coefficients were calculated for the area-under-the-curve of the change from baseline: subject-rated (.74) and observer-rated (.71) withdrawal, pulse (.88), systolic blood pressure (.58), diastolic blood pressure (.85), and skin temperature (.63).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenocorticotropic Hormone / blood
  • Adrenocorticotropic Hormone / metabolism
  • Adult
  • Blood Pressure / drug effects
  • Humans
  • Injections, Intravenous
  • Male
  • Methadone / therapeutic use
  • Naloxone* / administration & dosage
  • Naloxone* / pharmacology
  • Narcotic Antagonists* / administration & dosage
  • Narcotics
  • Reproducibility of Results*
  • Severity of Illness Index
  • Substance Withdrawal Syndrome / diagnosis*
  • Substance-Related Disorders / drug therapy

Substances

  • Narcotic Antagonists
  • Narcotics
  • Naloxone
  • Adrenocorticotropic Hormone
  • Methadone