Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM

Br J Haematol. 1996 Jan;92(1):159-60. doi: 10.1046/j.1365-2141.1996.275810.x.


In a 61-year-old man with glucose-6-phosphate dehydrogenase (G6PD) deficiency and poorly controlled non-insulin-dependent diabetes mellitus, an episode of acute haemolysis occurred after the administration of glyburide (glibenclamide). Erythrocyte fragmentation, with haemoglobin condensation zones next to clear zones, was observed on peripheral blood smears. Since autoimmune haemolysis was excluded on the basis of laboratory data, acute haemolysis was ascribed to G6PD deficiency.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Anemia, Hemolytic / chemically induced*
  • Diabetes Mellitus, Type 2 / complications*
  • Glucosephosphate Dehydrogenase Deficiency / complications*
  • Glyburide / adverse effects*
  • Humans
  • Hypoglycemic Agents / adverse effects*
  • Male
  • Middle Aged


  • Hypoglycemic Agents
  • Glyburide