The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

Nat Genet. 1996 Feb;12(2):159-67. doi: 10.1038/ng0296-159.


The t(7;11)(p15;p15) translocation is a recurrent chromosomal abnormality associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the molecular definition of this translocation. On chromosome 7 positional cloning revealed the consistent rearrangement of the HOXA9 gene, which encodes a class I homeodomain protein potentially involved in myeloid differentiation. On chromosome 11 the translocation targets the human homologue of NUP98, a member of the GLFG nucleoporin family. Chimaeric messages spliced over the breakpoint fuse the GLFG repeat domains of NUP98 in-frame to the HOXA9 homeobox. The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 7*
  • Cloning, Molecular
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / physiology
  • Humans
  • Leukemia, Myelomonocytic, Acute / genetics*
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Nuclear Pore Complex Proteins*
  • Nuclear Proteins / genetics*
  • RNA, Messenger / genetics
  • RNA, Neoplasm / genetics
  • Repetitive Sequences, Nucleic Acid / genetics
  • Sequence Analysis, DNA
  • Translocation, Genetic*


  • Homeodomain Proteins
  • Membrane Proteins
  • Nuclear Pore Complex Proteins
  • Nuclear Proteins
  • RNA, Messenger
  • RNA, Neoplasm
  • homeobox protein HOXA9
  • nuclear pore complex protein 98

Associated data

  • GENBANK/U41813
  • GENBANK/U41814
  • GENBANK/U41815