The varied lifestyles of intracellular pathogens within eukaryotic vacuolar compartments

Trends Microbiol. 1995 Oct;3(10):373-80. doi: 10.1016/s0966-842x(00)88982-9.


Many bacterial pathogens and eukaryotic parasites can enter mammalian cells and live intracellularly inside membrane-bound vacuoles. The intravacuolar lifestyle of these pathogens plays a key role in pathogenesis. Understanding the molecular basis of the development of these specialized intracellular compartments is critical to understanding how these organisms cause disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Physiological Phenomena*
  • Erythrocytes / microbiology
  • Erythrocytes / parasitology
  • Host-Parasite Interactions
  • Humans
  • Hydrogen-Ion Concentration
  • Parasites / physiology*
  • Phagosomes
  • Vacuoles / microbiology*
  • Vacuoles / parasitology*