BCG vaccination against tuberculosis: past disappointments and future hopes

Trends Microbiol. 1995 Oct;3(10):397-401. doi: 10.1016/s0966-842x(00)88986-6.


Three billion doses of the bacille Calmette-Guérin (BCG) vaccine have been given over the past 60 years. BCG has a widely variable ability to protect humans against tuberculosis. This article examines some of the reasons for this variability, and discusses ways in which BCG vaccination might be improved.

Publication types

  • Review

MeSH terms

  • Animals
  • BCG Vaccine / administration & dosage*
  • Forecasting
  • Humans
  • Tuberculosis / prevention & control*


  • BCG Vaccine